Antioxidant enzymes form the first line of defense against free radicals in organisms. Their
regulation depends mainly on the oxidant status of the cell, given that oxidants are their …

Exacerbation of hypoxic injury after reoxygenation is a crucial mechanism mediating organ
injury in transplantation, and in myocardial, hepatic, gastrointestinal, cerebral, renal, and …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the purpose of anti-
inflammation, antipyretic, and analgesia. For this aim, they are used for the alleviation of …

Tryptophan is an essential amino acid with a huge functional versatility, in addition to its
participation in protein synthesis. Because of the complexity of its metabolism, and the …

Melatonin acts through a series of molecular targets: the G-protein coupled receptors, MT1
and MT2, and a third binding site, MT3, recently identified as the enzyme NRH: quinone …

Melatonin, a pineal secretory product, synthesized from l‐tryptophan, has received
increased attention because of its antioxidative and immunomodulatory properties. It has …

Exogenous prostaglandins (PG) applied in small gastroprotective doses fail to affect healing
of gastro-duodenal ulcers but accelerate the healing when used in larger gastric inhibitory …

AIM: To investigate the effects of melatonin (MT) on the expression of inducible nitric oxide
synthase (iNOS) and cyclooxygenase-2 (COX-2) in rat models of colitis. METHODS: Healthy …

Art. 1.1475/ringraziamenti Page 1 European Review for Medical and Pharmacological Sciences
582 Abstract. – Background: Testicular tor- sion due to oxidative stress results in infertility and …

Background and objectives: toxic liver injury results in nitrooxidative stress. Melatonin is a
potent free radical scavenger, an inducible nitric oxide synthase (iNOS) inhibitor and an …