Advanced drug delivery and therapeutic strategies for tuberculosis treatment
A Nair, A Greeny, A Nandan, RK Sah, A Jose… - Journal of …, 2023 - Springer
Tuberculosis (TB) remains a significant global health challenge, necessitating innovative
approaches for effective treatment. Conventional TB therapy encounters several limitations …
approaches for effective treatment. Conventional TB therapy encounters several limitations …
Alginate nanoparticles: a potential drug carrier in tuberculosis treatment
Among all infectious diseases that afflict humans, tuberculosis (TB) remains the deadliest. At
present, epidemiologists estimate that one-third of the world population is infected with …
present, epidemiologists estimate that one-third of the world population is infected with …
Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis
We describe the design and synthesis of two isatin-tethered quinolines series (Q6a–h and
Q8a–h), in connection with our research interest in develo** novel isatin-bearing anti …
Q8a–h), in connection with our research interest in develo** novel isatin-bearing anti …
Oral proniosomal amitriptyline and liraglutide for management of diabetic neuropathy: Exceptional control over hyperglycemia and neuropathic pain
Exploitation of nanocarriers provides a compartment for enclosing drugs to protect them from
degradation and potentiate their therapeutic efficiency. In the current study, amitriptyline-and …
degradation and potentiate their therapeutic efficiency. In the current study, amitriptyline-and …
Development of potent nanosized carbonic anhydrase inhibitor for targeted therapy of hypoxic solid tumors
Overexpression of two carbonic anhydrase (CA) isoforms, CA IX and XII, in several hypoxic
solid tumors provides an extracellular hypoxic microenvironment, interferes with extra-and …
solid tumors provides an extracellular hypoxic microenvironment, interferes with extra-and …
Morphologic design of nanogold carriers for a carbonic anhydrase inhibitor: Effect on ocular retention and intraocular pressure
Morphologic design of nanomaterials for a diversity of biomedical applications is of
increasing interest. The aim of the current study is to construct therapeutic gold …
increasing interest. The aim of the current study is to construct therapeutic gold …
Discovery of pyrimidine-tethered benzothiazole derivatives as novel anti-tubercular agents towards multi- and extensively drug resistant Mycobacterium tuberculosis
In this study, new benzothiazole–pyrimidine hybrids (5a–c, 6, 7a–f, and 8–15) were
designed and synthesised. Two different functionalities on the pyrimidine moiety of lead …
designed and synthesised. Two different functionalities on the pyrimidine moiety of lead …
Identification of new anti-mycobacterial agents based on quinoline-isatin hybrids targeting enoyl acyl carrier protein reductase (InhA)
EF Khaleel, A Sabt, M Korycka-Machala, RM Badi… - Bioorganic …, 2024 - Elsevier
Tuberculosis (TB) is a global issue that poses a significant economic burden as a result of
the ongoing emergence of drug-resistant strains. The urgent requirement for the …
the ongoing emergence of drug-resistant strains. The urgent requirement for the …
Effective loading of incompatible drugs into nanosized vesicles: A strategy to allow concurrent administration of furosemide and midazolam in simulated clinical …
The current study aims to assess the use of nanocarriers to limit drug incompatibilities in
clinical settings, and thus eliminating serious clinical consequences (eg, catheter obstruction …
clinical settings, and thus eliminating serious clinical consequences (eg, catheter obstruction …
Design and synthesis of benzo[b]thiophene‐based hybrids as novel antitubercular agents against MDR/XDR Mycobacterium tuberculosis
In an effort to support the global fight against tuberculosis (TB), which is widely recognized
as the most lethal infectious disease worldwide, we present the design and synthesis of new …
as the most lethal infectious disease worldwide, we present the design and synthesis of new …