Proteins participate in various essential processes in vivo via interactions with other
molecules. Identifying the residues participating in these interactions not only provides …

During the process of protein folding, the amino acid residues along the polypeptide chain
interact with each other in a cooperative manner to form the stable native structure. The …

Comparative protein structure modeling predicts the three‐dimensional structure of a given
protein sequence (target) based primarily on its alignment to one or more proteins of known …

This work presents RaptorX, a statistical method for template‐based protein modeling that
improves alignment accuracy by exploiting structural information in a single or multiple …

We develop a new threading algorithm MUSTER by extending the previous sequence
profile–profile alignment method, PPA. It combines various sequence and structure …

The detection of ligand-binding sites is often the starting point for protein function
identification and drug discovery. Because of inaccuracies in predicted protein structures …

We have developed a new combined approach for ab initio protein structure prediction. The
protein conformation is described as a lattice chain connecting C α atoms, with attached C β …

A heavy atom distance‐dependent knowledge‐based pairwise potential has been
developed. This statistical potential is first evaluated and optimized with the native structure …

In this postgenomic era, the ability to identify protein–protein interactions on a genomic scale
is very important to assist in the assignment of physiological function. Because of the …

Steady progress has been made in the field of ab initio protein folding. A variety of methods
now allow the prediction of low-resolution structures of small proteins or protein fragments …