Molecular polymer bottlebrushes in nanomedicine: therapeutic and diagnostic applications
M Müllner - Chemical Communications, 2022 - pubs.rsc.org
Molecular polymer bottlebrushes are densely grafted, individual macromolecules with
nanoscale proportions. The last decade has seen an increased focus on this material class …
nanoscale proportions. The last decade has seen an increased focus on this material class …
Chemical recycling of polyolefins via ring-closing metathesis depolymerization
The current insufficient recycling of commodity polymer waste has resulted in pressing
environmental and human health issues in our modern society. In the quest for next …
environmental and human health issues in our modern society. In the quest for next …
Proteomimetic polymer blocks mitochondrial damage, rescues Huntington's neurons, and slows onset of neuropathology in vivo
Recently, it has been shown that blocking the binding of valosin-containing protein (VCP) to
mutant huntingtin (mtHtt) can prevent neuronal mitochondrial autophagy in Huntington's …
mutant huntingtin (mtHtt) can prevent neuronal mitochondrial autophagy in Huntington's …
Thrombospondin-1 proteomimetic polymers exhibit anti-angiogenic activity in a neovascular age-related macular degeneration mouse model
Neovascular age-related macular degeneration (nAMD) is the leading cause of blindness in
the developed world. Current therapy includes monthly intraocular injections of anti-VEGF …
the developed world. Current therapy includes monthly intraocular injections of anti-VEGF …
Controlled adsorption of multiple bioactive proteins enables targeted mast cell nanotherapy
Protein adsorption onto nanomaterials often results in denaturation and loss of bioactivity.
Controlling the adsorption process to maintain the protein structure and function has …
Controlling the adsorption process to maintain the protein structure and function has …
Design of biomaterials through direct ring-opening metathesis polymerisation of functionalised cyclic alkenes
Ring-opening metathesis polymerisation (ROMP) has become a popular method for
synthesising complex functional polymers owing to the high functional group tolerance of …
synthesising complex functional polymers owing to the high functional group tolerance of …
Proteomimetic Polymers Trigger Potent Antigen-Specific T Cell Responses to Limit Tumor Growth
Elicitation of effective antitumor immunity following cancer vaccination requires the selective
activation of distinct effector cell populations and pathways. Here we report a therapeutic …
activation of distinct effector cell populations and pathways. Here we report a therapeutic …
Inhibiting the Keap1/Nrf2 Protein‐Protein Interaction with Protein‐Like Polymers
KP Carrow, HL Hamilton, MP Hopps, Y Li… - Advanced …, 2024 - Wiley Online Library
Successful and selective inhibition of the cytosolic protein‐protein interaction (PPI) between
nuclear factor erythroid 2‐related factor 2 (Nrf2) and Kelch‐like ECH‐associating protein 1 …
nuclear factor erythroid 2‐related factor 2 (Nrf2) and Kelch‐like ECH‐associating protein 1 …
Conformational modulation and polymerization-induced folding of proteomimetic peptide brush polymers
Peptide-brush polymers generated by graft-through living polymerization of peptide-
modified monomers exhibit high proteolytic stability, therapeutic efficacy, and potential as …
modified monomers exhibit high proteolytic stability, therapeutic efficacy, and potential as …
Lipidation Alters the Structure and Hydration of Myristoylated Intrinsically Disordered Proteins
Lipidated proteins are an emerging class of hybrid biomaterials that can integrate the
functional capabilities of proteins into precisely engineered nano-biomaterials with potential …
functional capabilities of proteins into precisely engineered nano-biomaterials with potential …