The use of stem cells in regenerative medicine holds great promise for the cure of many
diseases, including type 1 diabetes mellitus (T1DM). Any potential stem-cell-based cure for …

Current approaches aiming to cure type 1 diabetes (T1D) have made a negligible number of
patients insulin-independent. In this review, we revisit the role of stem cell (SC)-based …

Background/Aims: Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion
to mediate β-cell dysfunction and β-cell loss in type 2 diabetes, a phenomenon known as …

The beamline design, microscope specifications, and initial results from the new mid-
infrared beamline (IRENI) are reviewed. Synchrotron-based spectrochemical imaging, as …

Aims. The goal of cell transcription for treatment of diabetes is to generate surrogate β‐cells
from an appropriate cell line. However, the induced replacement cells have showed less …

According to the Juvenile Diabetes Research Foundation (JDRF), almost 1. 25 million
people in the United States (US) have type 1 diabetes, which makes them dependent on …

Embryonic stem cells (ESCs) harbor the potential to generate every cell type of the body by
differentiation. The use of hESCs holds great promise for potential cell replacement …

Insulin-producing beta cells sourced from pluripotent stem cells hold great potential as a
virtually unlimited cell source to treat diabetes. Directed pancreatic differentiation protocols …

Pluripotent cell lines such as embryonic stem cells are an attractive source for a potential
cell replacement therapy. However, transplantation of differentiated cells harbors the risk of …

Importance of the field: β-Cell regeneration and β-cell preservation are two promising
therapeutic approaches for the management of patients with type 1 diabetes (T1D). Stem …