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Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling
A Perkins, KJ Nelson, D Parsonage, LB Poole… - Trends in biochemical …, 2015 - cell.com
Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …
Multiple functions and regulation of mammalian peroxiredoxins
SG Rhee, IS Kil - Annual review of biochemistry, 2017 - annualreviews.org
Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells
expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide (H2O2) at …
expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide (H2O2) at …
The conundrum of hydrogen peroxide signaling and the emerging role of peroxiredoxins as redox relay hubs
S Stöcker, K Van Laer, A Mijuskovic… - Antioxidants & redox …, 2018 - liebertpub.com
Abstract Significance: Hydrogen peroxide (H2O2) is known to act as a messenger in signal
transduction. How H2O2 leads to selective and efficient oxidation of specific thiols on …
transduction. How H2O2 leads to selective and efficient oxidation of specific thiols on …
Maintaining a healthy proteome during oxidative stress
D Reichmann, W Voth, U Jakob - Molecular cell, 2018 - cell.com
Some of the most challenging stress conditions that organisms encounter during their
lifetime involve the transient accumulation of reactive oxygen and chlorine species …
lifetime involve the transient accumulation of reactive oxygen and chlorine species …
The landscape of exosomal non-coding RNAs in breast cancer drug resistance, focusing on underlying molecular mechanisms
M Rezaee, F Mohammadi… - Frontiers in …, 2023 - frontiersin.org
Breast cancer (BC) is the most common malignancy among women worldwide. Like many
other cancers, BC therapy is challenging and sometimes frustrating. In spite of the various …
other cancers, BC therapy is challenging and sometimes frustrating. In spite of the various …
Protein quality control under oxidative stress conditions
Accumulation of reactive oxygen and chlorine species (RO/CS) is generally regarded to be a
toxic and highly undesirable event, which serves as contributing factor in aging and many …
toxic and highly undesirable event, which serves as contributing factor in aging and many …
Lifespan control by redox-dependent recruitment of chaperones to misfolded proteins
Caloric restriction (CR) extends the lifespan of flies, worms, and yeast by counteracting age-
related oxidation of H 2 O 2-scavenging peroxiredoxins (Prxs). Here, we show that …
related oxidation of H 2 O 2-scavenging peroxiredoxins (Prxs). Here, we show that …
Leishmania exosomes and other virulence factors: Impact on innate immune response and macrophage functions
VD Atayde, K Hassani, A da Silva Lira Filho… - Cellular …, 2016 - Elsevier
Leishmania parasites are the causative agents of the leishmaniases, a collection of vector-
borne diseases that range from simple cutaneous to fatal visceral forms. Employing potent …
borne diseases that range from simple cutaneous to fatal visceral forms. Employing potent …
Stress-activated chaperones: a first line of defense
W Voth, U Jakob - Trends in biochemical sciences, 2017 - cell.com
Proteins are constantly challenged by environmental stress conditions that threaten their
structure and function. Especially problematic are oxidative, acid, and severe heat stress …
structure and function. Especially problematic are oxidative, acid, and severe heat stress …
Peroxiredoxin 2: an important element of the antioxidant defense of the erythrocyte
I Sadowska-Bartosz, G Bartosz - Antioxidants, 2023 - mdpi.com
Peroxiredoxin 2 (Prdx2) is the third most abundant erythrocyte protein. It was known
previously as calpromotin since its binding to the membrane stimulates the calcium …
previously as calpromotin since its binding to the membrane stimulates the calcium …