Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that
regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural …

Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

Both activating and null mutations of proteins required for canonical WNT signaling have
revealed the importance of this pathway for normal skeletal development. However, tissue …

Chondrogenesis is a multistep process that is essential for endochondral bone formation.
Previous results have indicated a role for β-catenin and Wnt signaling in this pathway. Here …

An unanswered question in the field of signal transduction research is how different
signaling pathways are activated with strict specificity in a temporally and spatially controlled …

The observation that CD45+ stem cells injected into the circulation participate in muscle
regeneration raised the question of whether CD45+ stem cells resident in muscle play a …

Mammalian nephrons form as a result of a complex morphogenesis and patterning of a
simple epithelial precursor, the renal vesicle. Renal vesicles are established from a …