Acquisition of the ability to evade cellular suicide, or apoptosis, is one of the master switches
that contributes to cellular transformation and, ultimately, to invasive cancer. Much has been …

Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient
tumors with high microsatellite instability that demonstrate immune infiltration, suggesting …

IL-8, a member of the chemokine family, has been shown to play an important role in tumor
growth, angiogenesis, and metastasis. The objective of this study was to determine the …

Various conventional chemotherapeutic drugs can block angiogenesis or even kill activated,
dividing endothelial cells. Such effects may contribute to the antitumor efficacy of …

Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted
attention from several viewpoints of basic and translational research. Its cell cycle-regulated …

In a parallel study, Browder et al.(9) grew cyclophosphamide-resistant tumors (Lewis lung
carcinoma and EMT-6 breast carcinoma) in immunocompetent mice to focus more …

New data indicate that primary dysfunction in the tumour microenvironment, in addition to
epithelial dysfunction, can be crucial for carcinogenesis. These recent findings make a …

Tumor-associated fibroblasts are key regulators of tumorigenesis. In contrast to tumor cells,
which are genetically unstable and mutate frequently, the presence of genetically more …

A productive angiogenic response must couple to the survival machinery of endothelial cells
to preserve the integrity of newly formed vessels. Angiopoietin-1 (Ang-1) is an endothelium …

Angiogenesis plays a crucial role in wound healing by forming new blood vessels from
preexisting vessels by invading the wound clot and organizing in to a microvascular network …