The therapeutic potential of naringenin: a review of clinical trials

B Salehi, PVT Fokou, M Sharifi-Rad, P Zucca… - Pharmaceuticals, 2019 - mdpi.com
Naringenin is a flavonoid belonging to flavanones subclass. It is widely distributed in several
Citrus fruits, bergamot, tomatoes and other fruits, being also found in its glycosides form …

Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering

SM Nabavi, D Šamec, M Tomczyk, L Milella… - Biotechnology …, 2020 - Elsevier
Plants, fungi, and microorganisms are equipped with biosynthesis machinery for producing
thousands of secondary metabolites. These compounds have important functions in nature …

Engineering cellular metabolism

J Nielsen, JD Keasling - Cell, 2016 - cell.com
Metabolic engineering is the science of rewiring the metabolism of cells to enhance
production of native metabolites or to endow cells with the ability to produce new products …

Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

Q Liu, T Yu, X Li, Y Chen, K Campbell, J Nielsen… - Nature …, 2019 - nature.com
The production of bioactive plant compounds using microbial hosts is considered a safe,
cost-competitive and scalable approach to their production. However, microbial production …

Biosynthesis and regulation of anthocyanin pathway genes

L Sunil, NP Shetty - Applied Microbiology and Biotechnology, 2022 - Springer
Anthocyanins are the phenolic compounds responsible for coloring pigments in fruits and
vegetables. Anthocyanins offer a wide range of health benefits to human health. Their scope …

Chemistry and biological activities of flavonoids: an overview

S Kumar, AK Pandey - The scientific world journal, 2013 - Wiley Online Library
There has been increasing interest in the research on flavonoids from plant sources
because of their versatile health benefits reported in various epidemiological studies. Since …

Yeast systems biology: model organism and cell factory

J Nielsen - Biotechnology journal, 2019 - Wiley Online Library
For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a
cell factory for the production of bread, beer, and wine. In more recent years, this yeast has …

CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae

R Mans, HM van Rossum, M Wijsman… - FEMS yeast …, 2015 - academic.oup.com
A variety of techniques for strain engineering in Saccharomyces cerevisiae have recently
been developed. However, especially when multiple genetic manipulations are required …

[HTML][HTML] De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

M Li, KR Kildegaard, Y Chen, A Rodriguez… - Metabolic …, 2015 - Elsevier
Resveratrol is a natural antioxidant compound, used as food supplement and cosmetic
ingredient. Microbial production of resveratrol has until now been achieved by …

Engineering 4-coumaroyl-CoA derived polyketide production in Yarrowia lipolytica through a β-oxidation mediated strategy

CM Palmer, KK Miller, A Nguyen, HS Alper - Metabolic engineering, 2020 - Elsevier
Polyketides are a diverse class of molecules sought after for their valuable properties,
including as potential pharmaceuticals. Previously, we demonstrated that the oleaginous …