Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the
spine are biomechanically interdependent, typically occur in tandem, and have considerable …

The purpose of this review was to evaluate data generated by animal models of
intervertebral disc (IVD) degeneration published in the last decade and show how this has …

The aberrant mechanical microenvironment in degenerated tissues induces misdirection of
cell fate, making it challenging to achieve efficient endogenous regeneration. Herein, a …

Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies
low back pain. Overloading-induced cell death, especially endogenous stem cell death, is …

The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD)
necessary for sustaining the nutrition of the disc while distributing mechanical loads and …

Study Design. This article comprises a review of the literature. Objective. The purpose of this
study was to elucidate the different types of structural failures exhibited in intervertebral discs …

Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

Low back pain (LBP) is a chronic condition that can affect up to 80% of the global
population. It is the number one cause of disability worldwide and has enormous …

Low back pain (LBP) in one of the most disabling symptoms affecting nearly 80% of the
population worldwide. Its primary cause seems to be intervertebral disc degeneration (IDD) …

Increased tissue stiffness is associated with various pathological processes, such as fibrosis,
inflammation, and aging. The matrix stiffness of the nucleus pulposus (NP) tissues increases …