Ruthenium (II) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

MR Gill, JA Thomas - Chemical Society Reviews, 2012 - pubs.rsc.org
In the last few decades, coordination complexes based on d6 metal centres and polypyridyl
ligand architectures been developed as structure-and site-specific reversible DNA binding …

Anticancer activity of metal complexes: involvement of redox processes

U Jungwirth, CR Kowol, BK Keppler, CG Hartinger… - 2011 - liebertpub.com
Cells require tight regulation of the intracellular redox balance and consequently of reactive
oxygen species for proper redox signaling and maintenance of metal (eg, of iron and …

Rhodium (III)–Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy

YQ Gu, K Yang, QY Yang, HQ Li, MQ Hu… - Journal of Medicinal …, 2023 - ACS Publications
As a continuation of our endeavors in discovering metal-based drugs with cytotoxic and
antimetastatic activities, herein, we reported the syntheses of 11 new rhodium (III) …

Bioactive iridium and rhodium complexes as therapeutic agents

CH Leung, HJ Zhong, DSH Chan, DL Ma - Coordination Chemistry …, 2013 - Elsevier
Group 9 metal complexes based on iridium and rhodium have recently arisen as fascinating
potential alternatives to existing platinum and ruthenium metallodrugs. While long regarded …

[HTML][HTML] The role of surface functionality on acute cytotoxicity, ROS generation and DNA damage by cationic gold nanoparticles

A Chompoosor, K Saha, PS Ghosh… - Small (Weinheim an …, 2010 - ncbi.nlm.nih.gov
Gold nanoparticles (AuNPs) are promising materials for biomedical applications [1, 2] due to
their tunable surface properties [3] and extraordinary stability.[4] Additionally, the inert core …

DNA/protein binding, molecular docking, and in vitro anticancer activity of some thioether-dipyrrinato complexes

RK Gupta, G Sharma, R Pandey, A Kumar… - Inorganic …, 2013 - ACS Publications
Syntheses and characterizations of the arene ruthenium [(η6-C6H6) RuCl (4-mtdpm)](1),[(η6-
p-MeC6H4Pri) RuCl (4-mtdpm)](2), and structurally analogous rhodium/iridium complexes …

Recent development of copper (II) complexes of polypyridyl ligands in chemotherapy and photodynamic therapy

J Rani J, S Roy - ChemMedChem, 2023 - Wiley Online Library
Cancer is a deadly disease associated with abnormal cell growth and invasion to various
parts of the body. Many drugs such as cisplatin and carboplatin have been used for the …

Synthesis, antiproliferative activity and apoptosis-promoting effects of arene ruthenium (II) complexes with N, O chelating ligands

N Mohan, MKM Subarkhan, R Ramesh - Journal of Organometallic …, 2018 - Elsevier
New half sandwich arene ruthenium (II) complexes of the type [Ru (arene) Cl (L)](where
arene= benzene and p-cymene, L= thiophene benzhydrazone ligands) have been …

DNA binding and anti-cancer activity of redox-active heteroleptic piano-stool Ru (II), Rh (III), and Ir (III) complexes containing 4-(2-methoxypyridyl) …

RK Gupta, R Pandey, G Sharma, R Prasad… - Inorganic …, 2013 - ACS Publications
The synthesis of four novel heteroleptic dipyrrinato complexes [(η6-arene) RuCl (2-
pcdpm)](η6-arene= C6H6, 1; C10H14, 2) and [(η5-C5Me5) MCl (2-pcdpm)](M= Rh, 3; Ir, 4) …

[Ru(bpy)2(5-cyanouracil)2]2+ as a Potential Light-Activated Dual-Action Therapeutic Agent

RN Garner, JC Gallucci, KR Dunbar… - Inorganic Chemistry, 2011 - ACS Publications
The cation cis-[Ru (bpy) 2 (5CNU) 2] 2+(bpy= 2, 2′-bipyridine; 5CNU= 5-cyanouracil) was
synthesized and investigated for use as a potential light-activated dual-action therapeutic …