Role of glycosylation in nucleating protein folding and stability

NG Jayaprakash, A Surolia - Biochemical Journal, 2017 - portlandpress.com
Glycosylation constitutes one of the most common, ubiquitous and complex forms of post-
translational modification. It commences with the synthesis of the protein and plays a …

Significance of glycans in cellulolytic enzymes for lignocellulosic biorefinery–A review

CD Dong, AK Patel, A Madhavan, CW Chen… - Bioresource …, 2023 - Elsevier
Lignocellulosic (LC) biomass is the most abundant renewable resource for mankind
gravitating society towards sustainable solution for energy that can reduce the carbon …

Impact of N-linked glycosylation on therapeutic proteins

B Chen, W Liu, Y Li, B Ma, S Shang, Z Tan - Molecules, 2022 - mdpi.com
Therapeutic proteins have unique advantages over small-molecule drugs in the treatment of
various diseases, such as higher target specificity, stronger pharmacological efficacy and …

Distinct roles of N-and O-glycans in cellulase activity and stability

A Amore, BC Knott, NT Supekar, A Shajahan… - Proceedings of the …, 2017 - pnas.org
In nature, many microbes secrete mixtures of glycoside hydrolases, oxidoreductases, and
accessory enzymes to deconstruct polysaccharides and lignin in plants. These enzymes are …

Progress in ameliorating beneficial characteristics of microbial cellulases by genetic engineering approaches for cellulose saccharification

A Dadwal, S Sharma, T Satyanarayana - Frontiers in microbiology, 2020 - frontiersin.org
Lignocellulosic biomass is a renewable and sustainable energy source. Cellulases are the
enzymes that cleave β-1, 4-glycosidic linkages in cellulose to liberate sugars that can be …

Engineering enhanced cellobiohydrolase activity

LE Taylor, BC Knott, JO Baker, PM Alahuhta… - Nature …, 2018 - nature.com
Abstract Glycoside Hydrolase Family 7 cellobiohydrolases (GH7 CBHs) catalyze cellulose
depolymerization in cellulolytic eukaryotes, making them key discovery and engineering …

Chemical biology of glycoproteins: from chemical synthesis to biological impact

Y Li, AH Tran, SJ Danishefsky, Z Tan - Methods in Enzymology, 2019 - Elsevier
Recent advances have demonstrated the feasibility and robustness of chemical synthesis for
the production of homogeneously glycosylated protein forms (glycoforms). By taking …

Structural insight into why S-linked glycosylation cannot adequately mimic the role of natural O-glycosylation

C Chen, B Ma, Y Wang, Q Cui, L Yao, Y Li… - International Journal of …, 2023 - Elsevier
There is an increasing interest in using S-glycosylation as a replacement for the more
commonly occurring O-glycosylation, aiming to enhance the resistance of glycans against …

Tailoring in fungi for next generation cellulase production with special reference to CRISPR/CAS system

S Mondal, SK Halder, KC Mondal - Systems Microbiology and …, 2022 - Springer
Cellulose is the utmost plenteous source of biopolymer in our earth, and fungi are the most
efficient and ubiquitous organism in degrading the cellulosic biomass by synthesizing …

Chemically precise glycoengineering improves human insulin

X Guan, PK Chaffey, X Wei, DR Gulbranson… - ACS chemical …, 2018 - ACS Publications
Diabetes is a leading cause of death worldwide and results in over 3 million annual deaths.
While insulin manages the disease well, many patients fail to comply with injection …