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Role of glycosylation in nucleating protein folding and stability
Glycosylation constitutes one of the most common, ubiquitous and complex forms of post-
translational modification. It commences with the synthesis of the protein and plays a …
translational modification. It commences with the synthesis of the protein and plays a …
Significance of glycans in cellulolytic enzymes for lignocellulosic biorefinery–A review
Lignocellulosic (LC) biomass is the most abundant renewable resource for mankind
gravitating society towards sustainable solution for energy that can reduce the carbon …
gravitating society towards sustainable solution for energy that can reduce the carbon …
Impact of N-linked glycosylation on therapeutic proteins
B Chen, W Liu, Y Li, B Ma, S Shang, Z Tan - Molecules, 2022 - mdpi.com
Therapeutic proteins have unique advantages over small-molecule drugs in the treatment of
various diseases, such as higher target specificity, stronger pharmacological efficacy and …
various diseases, such as higher target specificity, stronger pharmacological efficacy and …
Distinct roles of N-and O-glycans in cellulase activity and stability
In nature, many microbes secrete mixtures of glycoside hydrolases, oxidoreductases, and
accessory enzymes to deconstruct polysaccharides and lignin in plants. These enzymes are …
accessory enzymes to deconstruct polysaccharides and lignin in plants. These enzymes are …
Progress in ameliorating beneficial characteristics of microbial cellulases by genetic engineering approaches for cellulose saccharification
Lignocellulosic biomass is a renewable and sustainable energy source. Cellulases are the
enzymes that cleave β-1, 4-glycosidic linkages in cellulose to liberate sugars that can be …
enzymes that cleave β-1, 4-glycosidic linkages in cellulose to liberate sugars that can be …
Engineering enhanced cellobiohydrolase activity
Abstract Glycoside Hydrolase Family 7 cellobiohydrolases (GH7 CBHs) catalyze cellulose
depolymerization in cellulolytic eukaryotes, making them key discovery and engineering …
depolymerization in cellulolytic eukaryotes, making them key discovery and engineering …
Chemical biology of glycoproteins: from chemical synthesis to biological impact
Y Li, AH Tran, SJ Danishefsky, Z Tan - Methods in Enzymology, 2019 - Elsevier
Recent advances have demonstrated the feasibility and robustness of chemical synthesis for
the production of homogeneously glycosylated protein forms (glycoforms). By taking …
the production of homogeneously glycosylated protein forms (glycoforms). By taking …
Structural insight into why S-linked glycosylation cannot adequately mimic the role of natural O-glycosylation
C Chen, B Ma, Y Wang, Q Cui, L Yao, Y Li… - International Journal of …, 2023 - Elsevier
There is an increasing interest in using S-glycosylation as a replacement for the more
commonly occurring O-glycosylation, aiming to enhance the resistance of glycans against …
commonly occurring O-glycosylation, aiming to enhance the resistance of glycans against …
Tailoring in fungi for next generation cellulase production with special reference to CRISPR/CAS system
S Mondal, SK Halder, KC Mondal - Systems Microbiology and …, 2022 - Springer
Cellulose is the utmost plenteous source of biopolymer in our earth, and fungi are the most
efficient and ubiquitous organism in degrading the cellulosic biomass by synthesizing …
efficient and ubiquitous organism in degrading the cellulosic biomass by synthesizing …
Chemically precise glycoengineering improves human insulin
Diabetes is a leading cause of death worldwide and results in over 3 million annual deaths.
While insulin manages the disease well, many patients fail to comply with injection …
While insulin manages the disease well, many patients fail to comply with injection …