Hierarchical structures of bone and bioinspired bone tissue engineering
Bone, as a mineralized composite of inorganic (mostly carbonated hydroxyapatite) and
organic (mainly type I collagen) phases, possesses a unique combination of remarkable …
organic (mainly type I collagen) phases, possesses a unique combination of remarkable …
Osteoblast and osteocyte: games without frontiers
The portrait of osteoblasts and osteocytes has been subjected to a revision, since a large
body of evidence is attributing these cells amazing roles both inside and outside the bone …
body of evidence is attributing these cells amazing roles both inside and outside the bone …
The mechanism of mineralization and the role of alkaline phosphatase in health and disease
H Orimo - Journal of Nippon Medical School, 2010 - jstage.jst.go.jp
Biomineralization is the process by which hydroxyapatite is deposited in the extracellular
matrix. Physiological mineralization occurs in hard tissues, whereas pathological …
matrix. Physiological mineralization occurs in hard tissues, whereas pathological …
The role of phosphatases in the initiation of skeletal mineralization
JL Millán - Calcified tissue international, 2013 - Springer
Endochondral ossification is a carefully orchestrated process mediated by promoters and
inhibitors of mineralization. Phosphatases are implicated, but their identities and functions …
inhibitors of mineralization. Phosphatases are implicated, but their identities and functions …
NT5E Mutations and Arterial Calcifications
C St. Hilaire, SG Ziegler, TC Markello… - … England Journal of …, 2011 - Mass Medical Soc
Background Arterial calcifications are associated with increased cardiovascular risk, but the
genetic basis of this association is unclear. Methods We performed clinical, radiographic …
genetic basis of this association is unclear. Methods We performed clinical, radiographic …
Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects
WL Tam, L Freitas Mendes, X Chen, R Lesage… - Stem cell research & …, 2021 - Springer
Background Bones have a remarkable capacity to heal upon fracture. Yet, in large defects or
compromised conditions healing processes become impaired, resulting in delayed or non …
compromised conditions healing processes become impaired, resulting in delayed or non …
Role of matrix vesicles in biomineralization
EE Golub - Biochimica et Biophysica Acta (BBA)-General Subjects, 2009 - Elsevier
BACKGROUND: Matrix vesicles have been implicated in the mineralization of calcified
cartilage, bone and dentin for more than 40 years. During this period, their exact role, if any …
cartilage, bone and dentin for more than 40 years. During this period, their exact role, if any …
Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models
Abstract Background Matrix vesicles (MVs) are released from hypertrophic chondrocytes
and from mature osteoblasts, the cells responsible for endochondral and membranous …
and from mature osteoblasts, the cells responsible for endochondral and membranous …
Current views on calcium phosphate osteogenicity and the translation into effective bone regeneration strategies
Calcium phosphate (CaP) has traditionally been used for the repair of bone defects because
of its strong resemblance to the inorganic phase of bone matrix. Nowadays, a variety of …
of its strong resemblance to the inorganic phase of bone matrix. Nowadays, a variety of …
[HTML][HTML] Characterisation of matrix vesicles in skeletal and soft tissue mineralisation
The importance of matrix vesicles (MVs) has been repeatedly highlighted in the formation of
cartilage, bone, and dentin since their discovery in 1967. These nano-vesicular structures …
cartilage, bone, and dentin since their discovery in 1967. These nano-vesicular structures …