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Development and therapeutic potential of adaptor-associated kinase 1 inhibitors in human multifaceted diseases
X **n, Y Wang, L Zhang, D Zhang, L Sha, Z Zhu… - European Journal of …, 2023 - Elsevier
Abstract Adaptor-Associated Kinase 1 (AAK1), a Ser/Thr protein kinase, responsible for
regulating clathrin-mediated endocytosis, is ubiquitous in the central nervous system (CNS) …
regulating clathrin-mediated endocytosis, is ubiquitous in the central nervous system (CNS) …
Recent progress in discovery of novel AAK1 inhibitors: from pain therapy to potential anti-viral agents
YH Yuan, ND Mao, JL Duan, H Zhang… - Journal of Enzyme …, 2023 - Taylor & Francis
Abstract Adaptor associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of Ser/Thr
kinases, is a specific key kinase regulating Thr156 phosphorylation at the μ2 subunit of the …
kinases, is a specific key kinase regulating Thr156 phosphorylation at the μ2 subunit of the …
Drebrin regulates collateral axon branching in cortical layer II/III somatosensory neurons
Proper cortical lamination is essential for cognition, learning, and memory. Within the
somatosensory cortex, pyramidal excitatory neurons elaborate axon collateral branches in a …
somatosensory cortex, pyramidal excitatory neurons elaborate axon collateral branches in a …
ECM29/proteasome-mediated self-antigen generation by CNS-resident neuroglia promotes regulatory T cell activation
SW Chen, Y Chu, CH Chu, XDT Pham, HP Ng, CL Guo… - Cell Reports, 2025 - cell.com
Proteasomes generate antigenic peptides presented on cell surfaces—a process that, in
neuroglia, is highly responsive to external stimuli. However, the function of the self-antigens …
neuroglia, is highly responsive to external stimuli. However, the function of the self-antigens …
Drebrin is required for myosin-facilitated actin cytoskeletal remodeling during pulmonary alveolar development
SE McGowan, N Gilfanov, MK Chandurkar… - American journal of …, 2024 - atsjournals.org
Alveolar septation increases gas-exchange surface area and requires coordinated
cytoskeletal rearrangement in lung fibroblasts (LFs) to balance the demands of contraction …
cytoskeletal rearrangement in lung fibroblasts (LFs) to balance the demands of contraction …
A modified motor-clutch model reveals that neuronal growth cones respond faster to soft substrates
Neuronal growth cones sense a variety of cues including chemical and mechanical ones to
establish functional connections during nervous system development. Substrate-cytoskeletal …
establish functional connections during nervous system development. Substrate-cytoskeletal …
DNA tension assays reveal that force-dependent integrin activation regulates neurite outgrowth in primary cortical neurons
Biomechanical inputs are ubiquitously present in biological systems and are known to
regulate various cell functions. In particular, neural cell development is sensitive to …
regulate various cell functions. In particular, neural cell development is sensitive to …