Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Over the years, click and bioorthogonal reactions have been the subject of considerable
research efforts. These high-performance chemical reactions have been developed to meet …

Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short
palindromic repeats) gene editing system often require viral vectors, which pose safety …

The intracellular delivery of biofunctional enzymes or therapeutic proteins through systemic
administration is of great importance in therapeutic intervention of various diseases …

Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …

Patients with acute myeloid leukaemia who relapse following therapy have few treatment
options and face poor outcomes. Immune checkpoint inhibition, for example, by antibody …

Nanomedicines afford unique advantages in therapeutic intervention against tumors.
However, conventional nanomedicines have failed to achieve the desired effect against …

Cancer-associated stimuli-responsive nanosystems have been increasingly considered for
the delivery of anticancer drugs, which primarily target the tumor microenvironment and/or …

Cytosolic protein delivery is a prerequisite for protein‐based biotechnologies and
therapeutics on intracellular targets. Polymers that can complex with proteins to form nano …

Proteins and peptides have played a pivotal role in revolutionizing disease treatment over
the last century. Despite their commercial success, protein therapeutics can be eliminated or …