Rapid advances in nanopore technologies for sequencing single long DNA and RNA
molecules have led to substantial improvements in accuracy, read length and throughput …

Long-read sequencing (LRS) technologies have provided extremely powerful tools to
explore genomes. While in the early years these methods suffered technical limitations, they …

Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been
difficult in part because a simple method to simultaneously quantify their abundance and …

Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …

Beyond transferring genetic information, RNAs are molecules with diverse functions that
include catalyzing biochemical reactions and regulating gene expression. Most of these …

Although the significance of chemical modifications on RNA is acknowledged, the
evolutionary benefits and specific roles in human immunodeficiency virus (HIV-1) replication …

There has been significant progress made in the field of nanopore biosensor development
and sequencing applications, which address previous limitations that restricted widespread …

Nanopore direct RNA sequencing (DRS) has emerged as a powerful tool for RNA
modification identification. However, concurrently detecting multiple types of modifications in …

O-methylation (Nm) is a prominent RNA modification well known in noncoding RNAs and
more recently also found at many mRNA internal sites. However, their function and base …

Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution map** of these modifications is …