A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Emotion, memories and behaviour emerge from the coordinated activities of regions
connected by the limbic system. Here, we propose an update of the limbic model based on …

The structure of the brain is constantly changing from birth throughout the lifetime, meaning
that normal aging, free from dementia, is associated with structural brain changes. This …

In the present meta-analysis, we integrated findings from 228 studies on the association of
six caregiving-related stressors and caregiving uplifts with burden and depressed mood …

Air pollution is a serious environmental problem. We investigated whether residency in cities
with high air pollution is associated with neuroinflammation/neurodegeneration in healthy …

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease. At the
time of clinical manifestation of dementia, significant irreversible brain damage is already …

The amyloid hypothesis (AH) of Alzheimer's disease (AD) posits that the fundamental cause
of AD is the accumulation of the peptide amyloid beta (Aβ) in the brain. This hypothesis has …

Nearly twice as many participants are represented in the current literature than were
available at the time of the last major meta-analytic neurocognitive examination of …

We collected MRI diffusion tensor imaging data from 80 younger (20–32 years) and 63 older
(60–71 years) healthy adults. Tract-based spatial statistics (TBSS) analysis revealed that …

Background Loss of brain white matter microstructure is presumed to be an early sign of
neurodegenerative disease. Yet, little is known on microstructural changes of various white …