DNA methylation patterns are set up early in mammalian development and are then copied
during the division of somatic cells. A long-established model for the maintenance of these …

In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …

DNA methylation plays a critical role in the regulation and maintenance of cell-type specific
transcriptional programs. Targeted epigenome editing is an emerging technology to …

Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …

Using peptide arrays and binding to native histone proteins, we show that the ADD domain
of Dnmt3a specifically interacts with the H3 histone 1–19 tail. Binding is disrupted by di-and …

DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …

Determining the effect of DNA methylation on chromatin structure and function in higher
organisms is challenging due to the extreme complexity of epigenetic regulation. We studied …

Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …

The methylation of mammalian DNA, primarily at CpG dinucleotides, has long been
recognized to play a major role in controlling gene expression, among other functions. Given …

Mammalian euchromatic gene silencing results from the combined repressive effects of
histone and DNA methyltransferases. Little is known of the mechanism by which these …