With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …

There have been several recent studies addressing the genetic architecture of depression.
This review serves to take stock of what is known now about the genetics of depression, how …

For many years, psychiatrists have tried to understand factors involved in response to
medications or psychotherapies, in order to personalize their treatment choices. There is …

While contemporary psychiatry seeks the mechanisms of mental disorders in neurobiology,
mental health problems clearly depend on developmental processes of learning and …

Background Antidepressants are a first-line treatment for depression. However, only a third
of individuals experience remission after the first treatment. Common genetic variation, in …

Abstract Treatment-resistant depression (TRD) is a major contributor to the disability caused
by major depressive disorder (MDD). Primary care electronic health records provide an …

Importance Antidepressant responses and the phenotype of treatment-resistant depression
(TRD) are believed to have a genetic basis. Genetic susceptibility between the TRD …

Background Understanding the genetic underpinnings of antidepressant treatment response
in unipolar major depressive disorder (MDD) can be useful in identifying patients at risk for …

Over the last years, the decreased costs and enhanced accessibility to large genome-wide
association studies datasets have laid the foundations for the development of polygenic risk …

In the past two decades, significant progress has been made in the development of
polygenic scores (PGSs). One specific application of PGSs is the development and potential …