Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

Mitophagy is an essential mitochondrial quality control mechanism that eliminates damaged
mitochondria and the production of reactive oxygen species (ROS). The relationship …

Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …

Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively
termed mitochondrial quality control mechanisms, including fusion and fission, degradation …

Mitochondrial dysfunction constitutes one of the hallmarks of aging and is characterized by
irregular mitochondrial morphology, insufficient ATP production, accumulation of …

Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a
surge of patient numbers in the coming decades in view of the emerging worldwide ageing …

Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative
disorders such as Down syndrome (DS) and Alzheimer's disease (AD). Using a high …