Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

CA Akdis - Nature Reviews Immunology, 2021 - nature.com
There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …

Gut microbiota and dysbiosis in Alzheimer's disease: implications for pathogenesis and treatment

S Liu, J Gao, M Zhu, K Liu, HL Zhang - Molecular neurobiology, 2020 - Springer
Understanding how gut flora influences gut-brain communications has been the subject of
significant research over the past decade. The broadening of the term “microbiota-gut-brain …

Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation

S Romano, GM Savva, JR Bedarf, IG Charles… - npj Parkinson's …, 2021 - nature.com
The gut microbiota is emerging as an important modulator of neurodegenerative diseases,
and accumulating evidence has linked gut microbes to Parkinson's disease (PD) …

Gut microbiome composition may be an indicator of preclinical Alzheimer's disease

AL Ferreiro, JH Choi, J Ryou, EP Newcomer… - Science translational …, 2023 - science.org
Alzheimer's disease (AD) pathology is thought to progress from normal cognition through
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …

The progress of gut microbiome research related to brain disorders

S Zhu, Y Jiang, K Xu, M Cui, W Ye, G Zhao… - Journal of …, 2020 - Springer
There is increasing evidence showing that the dynamic changes in the gut microbiota can
alter brain physiology and behavior. Cognition was originally thought to be regulated only by …

Gut–brain axis: role of gut microbiota on neurological disorders and how probiotics/prebiotics beneficially modulate microbial and immune pathways to improve brain …

K Suganya, BS Koo - International journal of molecular sciences, 2020 - mdpi.com
The gut microbiome acts as an integral part of the gastrointestinal tract (GIT) that has the
largest and vulnerable surface with desirable features to observe foods, nutrients, and …

The intestinal barrier in disorders of the central nervous system

C Pellegrini, M Fornai, V D'Antongiovanni… - The lancet …, 2023 - thelancet.com
The intestinal barrier, which primarily consists of a mucus layer, an epithelial barrier, and a
gut vascular barrier, has a crucial role in health and disease by facilitating nutrient …

Oral administration of resveratrol-selenium-peptide nanocomposites alleviates Alzheimer's disease-like pathogenesis by inhibiting Aβ aggregation and regulating gut …

C Li, N Wang, G Zheng, L Yang - ACS Applied Materials & …, 2021 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disease associated with amyloid-β (Aβ)
deposition, leading to neurotoxicity (oxidative stress and neuroinflammation) and gut …

[HTML][HTML] The potential mechanism of postoperative cognitive dysfunction in older people

X Lin, Y Chen, P Zhang, G Chen, Y Zhou, X Yu - Experimental gerontology, 2020 - Elsevier
Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which
seriously threatens the quality of patients' life, especially the older people. Accumulating …

Metal drugs and the anticancer immune response

B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …