The mammalian target of rapamycin, mTOR is the master regulator of a cell's growth and
metabolic state in response to nutrients, growth factors and many extracellular cues. Its …

The term “resilience” refers to the ability to adapt successfully to stress, trauma and
adversity, enabling individuals to avoid stress-induced mental disorders such as depression …

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

Pancreatic β cells differentiate during fetal life, but only postnatally acquire the capacity for
glucose-stimulated insulin secretion (GSIS). How this happens is not clear. In exploring what …

Aims: To explore the molecular mechanism by which 17β-estradiol (estrogen 2, E2)
regulates glucose transporter 2 (GLUT2) and insulin secretion in islet β cells through G …

Mechanistic target of rapamycin (mTOR) signaling functions as a central regulator of cellular
metabolism, growth, and survival in response to hormones, growth factors, nutrients, energy …

Discovering safe and effective drugs that promote neuron regeneration is an essential
strategy for the recovery of central nervous system injuries. In this study, we found that L …

Pancreatic β-cells are the only type of cells that can control glycemic levels via insulin
secretion. Thus, to explore the mechanisms underlying pancreatic β-cell failure, many …

Maternal low-protein diet (LP) throughout gestation affects pancreatic β-cell fraction of the
offspring at birth, thus increasing their susceptibility to metabolic dysfunction and type 2 …

Aim/hypothesis Hyperglycaemia is associated with alpha cell dysfunction, leading to
dysregulated glucagon secretion in type 1 and type 2 diabetes; however, the mechanisms …