Critical Care Medicine SCCM Pediatric Critical Care Medicine Critical Care Explorations Log
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Acute metabolic acidosis is associated with increased morbidity and mortality because of its
depressive effects on cardiovascular function, facilitation of cardiac arrhythmias, stimulation …

Objectives: During circulatory failure, the ultimate goal of treatments that increase cardiac
output is to reduce tissue hypoxia. This can only occur if oxygen consumption depends on …

Purpose Septic shock has been associated with microvascular alterations and these in turn
with the development of organ dysfunction. Despite advances in video microscopic …

Objective To test the hypothesis that, in resuscitated septic shock patients, central venous-to-
arterial carbon dioxide difference [P (cv-a) CO 2] may serve as a global index of tissue …

The mixed venous-to-arterial carbon dioxide (CO2) tension difference [P (va) CO2] is the
difference between carbon dioxide tension (PCO2) in mixed venous blood (sampled from a …

Objective: Under conditions of tissue hypoxia total CO 2 production (VCO 2) should be less
reduced than O 2 consumption (VO 2) since an anaerobic CO 2 production should occur …

Monitoring of tissue perfusion is an essential step in the management of acute circulatory
failure. The presence of cellular dysfunction has been a basic component of shock definition …

Introduction Venous-to-arterial carbon dioxide difference (Pv-aCO 2) may reflect the
adequacy of blood flow during shock states. We sought to test whether the development of …

Introduction Central venous oxygen saturation (ScvO 2) is a useful therapeutic target in
septic shock and high-risk surgery. We tested the hypothesis that central venous-to-arterial …