Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits

A Casamayor, J Ariño - Advances in Protein Chemistry and Structural …, 2020 - Elsevier
Protein phosphatase 1 is a major Ser/Thr protein phosphatase activity in eukaryotic cells. It
is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts …

Molecular epidemiology, in vitro susceptibility and exoenzyme screening of Malassezia clinical isolates

W Li, ZW Zhang, Y Luo, N Liang… - Journal of Medical …, 2020 - microbiologyresearch.org
Introduction. Malassezia folliculitis (MF) and pityriasis versicolor (PV) are common
dermatoses caused by Malassezia species. Their molecular epidemiology, drug …

Features of the rare pathogen Meyerozyma guilliermondii strain SO and comprehensive in silico analyses of its adherence-contributing virulence factor agglutinin …

SJ Lim, ND Muhd Noor, S Sabri… - Journal of …, 2023 - Taylor & Francis
Meyerozyma guilliermondii is a rare yeast pathogen contributing to the deadly invasive
candidiasis. M. guilliermondii strain SO, as a promising protein expression host, showed …

VSpipe-GUI, an Interactive Graphical User Interface for Virtual Screening and Hit Selection

R Hussain, AS Hackett, S Álvarez-Carretero… - International Journal of …, 2024 - mdpi.com
Virtual screening of large chemical libraries is essential to support computer-aided drug
development, providing a rapid and low-cost approach for further experimental validation …

State of the Art in Protein–protein Interactions Within the Fungi Kingdom

TG Santos, KSF Silva, RM Lima, LC Silva… - Future …, 2023 - Taylor & Francis
Proteins rarely exert their function by themselves. Protein–protein interactions (PPIs)
regulate virtually every biological process that takes place in a cell. Such interactions are …

A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis

J Adams, BP Thornton, L Tabernero - International Journal of Molecular …, 2021 - mdpi.com
The kinase interaction motif protein tyrosine phosphatases (KIM-PTPs), HePTP, PTPSL and
STEP, are involved in the negative regulation of mitogen-activated protein kinase (MAPK) …

[BOOK][B] The computational selection of druggable targets for the development of antifungals

B Thornton - 2022 - search.proquest.com
Fungal infections are a serious concern to the health and wellbeing of people worldwide. Up
to 1.2 billion people a year suffer from fungal infections, although the majority of these …