In any biomedical and chemical context, a truthful description of chemical constitution
requires coverage of both structure and purity. This qualification affects all drug molecules …

NF-κB may be a potential therapeutic target for acute myelogenous leukemia (AML)
because NF-κB activation is found in primitive human AML blast cells. In this report, we …

Enigmazole A (1), a novel phosphate-containing macrolide, was isolated from a Papua New
Guinea collection of the marine sponge Cinachyrella enigmatica. The structure of 1 …

Protein sumoylation is a dynamic posttranslational modification involved in diverse
biological processes during cellular homeostasis and development. Recently sumoylation …

The purpose of this present study is to prepare NF-κB/p65 antisense oligonucleotide loaded
chitosan nanoparticles (NPs) and evaluate their physicochemical characterization and …

Tumor-associated myeloid cells, including dendritic cells (DCs) and macrophages, are
immune suppressive. This study demonstrates a novel mechanism involving FOXO3 and NF …

Nuclear factor-κB (NF-κB) is a central regulator of immune response and a potential target
for develo** anti-inflammatory agents. Mechanistic studies suggest that compounds that …

Background BMP signaling pathway is critical for vertebrate development and tissue
homeostasis. High-throughput molecular genetic screening may reveal novel players …

Context: Epidioxy sterols and sterols with special side chains, such as hydroperoxyl sterols,
usually obtained from marine natural products, are attractive for bioactivities. Objective: To …

Eight new compounds, sinulolides A–H (1–8), along with two known compounds, α-methoxy-
2, 3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral …