Resistant hypertension: detection, evaluation, and management: a scientific statement from the American Heart Association
Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …
U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia
WT Crawley, CG Jungels, KR Stenmark, MA Fini - Redox Biology, 2022 - Elsevier
Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …
Genome-wide analyses identify KIF5A as a novel ALS gene
To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 …
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 …
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
Nature genetics, 2015 - nature.com
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is
largely based on genome-wide association study (GWAS) analysis of common SNPs …
largely based on genome-wide association study (GWAS) analysis of common SNPs …
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
GB Ehret, T Ferreira, DI Chasman, AU Jackson… - Nature …, 2016 - nature.com
To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …
Salt sensitivity of blood pressure: a scientific statement from the American Heart Association
F Elijovich, MH Weinberger, CAM Anderson… - …, 2016 - Am Heart Assoc
Hypertension is available at http://hyper. ahajournals. org DOI: 10.1161/HYP.
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
Genetic and molecular aspects of hypertension
Until recently, significant advances in our understanding of the mechanisms of blood
pressure regulation arose from studies of monogenic forms of hypertension and …
pressure regulation arose from studies of monogenic forms of hypertension and …
Genes for blood pressure: an opportunity to understand hypertension
GB Ehret, MJ Caulfield - European heart journal, 2013 - academic.oup.com
Hypertension (HTN) is quantitatively the major cardiovascular risk factor and responsible
for∼ 50% of cardiovascular morbidity and mortality. Blood pressure (BP) is also a classical …
for∼ 50% of cardiovascular morbidity and mortality. Blood pressure (BP) is also a classical …
The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease
Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly
with traditional risk factors precipitates their manifestation. Whereas the implications of a …
with traditional risk factors precipitates their manifestation. Whereas the implications of a …