Untargeted metabolomics strategies—challenges and emerging directions

AC Schrimpe-Rutledge, SG Codreanu… - Journal of the …, 2016 - ACS Publications
Metabolites are building blocks of cellular function. These species are involved in enzyme-
catalyzed chemical reactions and are essential for cellular function. Upstream biological …

[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

LM Butler, Y Perone, J Dehairs, LE Lupien… - Advanced drug delivery …, 2020 - Elsevier
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Ion mobility spectrometry: fundamental concepts, instrumentation, applications, and the road ahead

JN Dodds, ES Baker - Journal of the American Society for Mass …, 2019 - ACS Publications
Ion mobility spectrometry (IMS) is a rapid separation technique that has experienced
exponential growth as a field of study. Interfacing IMS with mass spectrometry (IMS-MS) …

Fundamentals of ion mobility spectrometry

V Gabelica, E Marklund - Current opinion in chemical biology, 2018 - Elsevier
Highlights•CCS distributions and shifts contain valuable information about
analytes.•Compound-dependent effects of gas, field and temperature explain calibration …

Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics

G Paglia, AJ Smith, G Astarita - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

Deep-profiling of phospholipidome via rapid orthogonal separations and isomer-resolved mass spectrometry

T **a, F Zhou, D Zhang, X **, H Shi, H Yin… - Nature …, 2023 - nature.com
A lipidome comprises thousands of lipid species, many of which are isomers and isobars.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …

High-end ion mobility mass spectrometry: A current review of analytical capacity in omics applications and structural investigations

DG Delafield, G Lu, CJ Kaminsky, L Li - TrAC Trends in Analytical …, 2022 - Elsevier
Mass spectrometry-based biomolecular analyses have become permanent fixtures of
academic, industrial, and clinical research settings. The rise in utilization of mass …

Recommendations for good practice in MS-based lipidomics

HC Köfeler, R Ahrends, ES Baker, K Ekroos, X Han… - Journal of lipid …, 2021 - ASBMB
In the last 2 decades, lipidomics has become one of the fastest expanding scientific
disciplines in biomedical research. With an increasing number of new research groups to …

Single‐cell mass spectrometry approaches to explore cellular heterogeneity

L Zhang, A Vertes - Angewandte Chemie International Edition, 2018 - Wiley Online Library
Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …

Ion mobility conformational lipid atlas for high confidence lipidomics

KL Leaptrot, JC May, JN Dodds, JA McLean - Nature communications, 2019 - nature.com
Lipids are highly structurally diverse molecules involved in a wide variety of biological
processes. Here, we use high precision ion mobility-mass spectrometry to compile a …