Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy
Significance: Extensive research during the last quarter century has revealed that reactive
oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role …
oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role …
[HTML][HTML] Phase 3 trials of stereotactic radiosurgery with or without whole-brain radiation therapy for 1 to 4 brain metastases: individual patient data meta-analysis
Purpose To perform an individual patient data (IPD) meta-analysis of randomized controlled
trials evaluating stereotactic radiosurgery (SRS) with or without whole-brain radiation …
trials evaluating stereotactic radiosurgery (SRS) with or without whole-brain radiation …
Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG …
Purpose Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may
play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid …
play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid …
Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial
Background To determine the protective effects of memantine on cognitive function in
patients receiving whole-brain radiotherapy (WBRT). Methods Adult patients with brain …
patients receiving whole-brain radiotherapy (WBRT). Methods Adult patients with brain …
A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three …
R Soffietti, M Kocher, UM Abacioglu, S Villa… - Journal of clinical …, 2013 - ascopubs.org
Purpose This phase III trial compared adjuvant whole-brain radiotherapy (WBRT) with
observation after either surgery or radiosurgery of a limited number of brain metastases in …
observation after either surgery or radiosurgery of a limited number of brain metastases in …
Randomized phase III trial of prophylactic cranial irradiation with or without hippocampal avoidance for small-cell lung cancer (PREMER): a GICOR-GOECP-SEOR …
PURPOSE Radiation dose received by the neural stem cells of the hippocampus during
whole-brain radiotherapy has been associated with neurocognitive decline. The key …
whole-brain radiotherapy has been associated with neurocognitive decline. The key …
Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202)
JL Rubenstein, ED Hsi, JL Johnson… - Journal of Clinical …, 2013 - ascopubs.org
Purpose Concerns regarding neurocognitive toxicity of whole-brain radiotherapy (WBRT)
have motivated development of alternative, dose-intensive chemotherapeutic strategies as …
have motivated development of alternative, dose-intensive chemotherapeutic strategies as …
Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors
PURPOSE: To prospectively evaluate the association between hippocampal dose and long-
term neurocognitive function (NCF) impairment for benign or low-grade adult brain tumors …
term neurocognitive function (NCF) impairment for benign or low-grade adult brain tumors …
Non–small cell lung cancer
Most patients with non–small cell lung cancer (NSCLC) are diagnosed with advanced
cancer. These guidelines only include information about stage IV NSCLC. Patients with …
cancer. These guidelines only include information about stage IV NSCLC. Patients with …
A multi-institutional prospective observational study of stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901 study update): irradiation …
Purpose The JLGK0901 study showed the noninferiority of stereotactic radiosurgery (SRS)
alone as initial treatment of 5 to 10 brain metastases (BMs) compared with 2 to 4 BMs in …
alone as initial treatment of 5 to 10 brain metastases (BMs) compared with 2 to 4 BMs in …