The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

Parasitic helminths have coevolved with humans over millennia, intricately refining and
develo** an array of mechanisms to suppress or skew the host's immune system, thereby …

Parasitic diseases represent major global health problems of immense proportion.
Schistosomiasis, malaria, leishmaniasis, Chagas disease, and African slee** sickness …

The intestinal helminth parasite, Heligmosomoides polygyrus bakeri offers a tractable
experimental model for human hookworm infections such as Ancylostoma duodenale and …

Parasitic worms alter their host's immune system to diminish the inflammatory responses
directed against them, using very efficient immunomodulating molecules. We have …

Background The cystatin superfamily comprises cysteine protease inhibitors that play key
regulatory roles in protein degradation processes. Although they have been the subject of …

The concept that parasites may utilize proteinase inhibitors to survive within the host has
been with us for 100 years. Given that we now know that proteinases are involved in key …

The activation of Trichinella spiralis muscle larvae (ML) by exposure to intestinal contents or
bile and the intestinal epithelial cells (IECs) themselves are two pivotal requirements for the …

Parasitic helminths reside in immunologically-exposed extracellular locations within their
hosts, yet they are capable of surviving for extended periods. To enable this survival, these …

Helminths are master regulators of host immune responses utilising complex mechanisms to
dampen host protective Th2‐type responses and favour long‐term persistence. Such …