Conventional administration of drugs is limited by poor water solubility, low permeability,
and mediocre targeting. Safe and effective delivery of drugs and therapeutic agents remains …

The biological response to biomaterials plays a crucial role in selecting suitable materials for
the formulation and development of tissue engineering platforms. Biodegradation is one of …

In recent years it is shown that mechanochemical strategies can be beneficial in directed
conversions of organic compounds. Finding new reactions proved difficult, and due to the …

Internuclear distances represent one of the main structural constraints in molecular structure
determination using solid-state NMR spectroscopy, complementing chemical shifts and …

Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …

Despite the boom in biologics over the past decade, the intrinsic instability of these large
molecules poses significant challenges to formulation development. Almost half of all …

Mannitol, leucine, and trehalose have been widely used in spray-dried formulations,
especially for inhalation formulations. The individual contribution of these excipients on …

In the fields of medicine and health, traditional high-performance liquid chromatography or
UV-visible spectrophotometry is generally used for substance quantification. However, over …

The determination of intracellular drug concentrations can provide a better understanding of
the drug function and efficacy. Ideally, this should be performed nondestructively, with no …

Crystallization is a widely used purification technique in the manufacture of active
pharmaceutical ingredients (APIs) and precursor molecules. However, when impurities and …