Diabetic nephropathy is a common complication of type I and type II diabetes, in which renal
glomeruli are destroyed, resulting in renal damage, proteinuria, and hypertension …

Metabolic homeostasis requires dynamic catabolic and anabolic processes. Autophagy, an
intracellular lysosomal degradative pathway, can rewire cellular metabolism linking …

Lipotoxicity, induced by saturated fatty acid (SFA)-mediated cell death, plays an important
role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The KEAP1 (kelch like …

Liver fibrosis is characterized by the excessive deposition and accumulation of extracellular
matrix components, mainly collagens, and occurs in response to a broad spectrum of …

Although advances in medical technology and health care have improved the early
diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity …

Autophagy is the liver cell energy recycling system regulating a variety of homeostatic
mechanisms. Damaged organelles, lipids and proteins are degraded in the lysosomes and …

In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-
sensitizing effect. The binding of adiponectin with its specific receptors induces the activation …

The transcription factor EB (TFEB) is a master regulator of lysosomal function and
autophagy. Mechanistic target of rapamycin (mTOR)-mediated phosphorylation on TFEB is …

Objective Non-alcoholic fatty liver disease is characterized by high hepatic triacylglycerol
contents, which is associated with endoplasmic reticulum (ER) stress and insulin resistance …

Background Calcium is a ubiquitous intracellular messenger that regulates the expression of
various genes involved in cell proliferation, differentiation, and motility. The involvement of …