Digital biomarkers in multiple sclerosis

A Dillenseger, ML Weidemann, K Trentzsch, H Inojosa… - Brain sciences, 2021 - mdpi.com
For incurable diseases, such as multiple sclerosis (MS), the prevention of progression and
the preservation of quality of life play a crucial role over the entire therapy period. In MS …

Oral and laryngeal diadochokinesis across the life span: A sco** review of methods, reference data, and clinical applications

RD Kent, Y Kim, L Chen - Journal of Speech, Language, and Hearing …, 2022 - pubs.asha.org
Purpose: The aim of this study was to conduct a sco** review of research on oral and
laryngeal diadochokinesis (DDK) in children and adults, either typically …

[HTML][HTML] From prodromal stages to clinical trials: The promise of digital speech biomarkers in Parkinson's disease

J Rusz, P Krack, E Tripoliti - Neuroscience & Biobehavioral Reviews, 2024 - Elsevier
Speech impairment is a common and disabling symptom in Parkinson's disease (PD),
affecting communication and quality of life. Advances in digital speech processing and …

What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis

G Noffs, T Perera, SC Kolbe, CJ Shanahan… - Autoimmunity …, 2018 - Elsevier
Importance Multiple sclerosis produces neurological impairments that are variable in
duration, severity and quality. Speech is frequently impaired, resulting in decreased …

Speech deficits in multiple sclerosis: a narrative review of the existing literature

P Plotas, V Nanousi, A Kantanis, E Tsiamaki… - European Journal of …, 2023 - Springer
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating autoimmune disease.
MS patients deal with motor and sensory impairments, visual disabilities, cognitive …

Automatic speech recognition in neurodegenerative disease

BG Schultz, VSA Tarigoppula, G Noffs, S Rojas… - International Journal of …, 2021 - Springer
Automatic speech recognition (ASR) could potentially improve communication by providing
transcriptions of speech in real time. ASR is particularly useful for people with progressive …

Speech metrics, general disability, brain imaging and quality of life in multiple sclerosis

G Noffs, FMC Boonstra, T Perera… - European Journal of …, 2021 - Wiley Online Library
Background and purpose Objective measurement of speech has shown promising results to
monitor disease state in multiple sclerosis. In this study, we characterize the relationship …

Assessing clinical utility of machine learning and artificial intelligence approaches to analyze speech recordings in multiple sclerosis: A pilot study

E Svoboda, T Bořil, J Rusz, T Tykalová… - Computers in biology …, 2022 - Elsevier
Background An early diagnosis together with an accurate disease progression monitoring of
multiple sclerosis is an important component of successful disease management. Prior …

A cross-sectional study of perceptual and acoustic voice characteristics in healthy aging

BG Schultz, S Rojas, M St John, E Kefalianos… - Journal of Voice, 2023 - Elsevier
Purpose The human voice qualitatively changes across the lifespan. Although some of these
vocal changes may be pathologic, other changes likely reflect natural physiological aging …

Quantitative Speech Assessment in Ataxia—Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Markers

AP Vogel, A Sobanska, A Gupta, G Vasco… - The Cerebellum, 2024 - Springer
Dysarthria is a common and debilitating symptom of many neurodegenerative diseases,
including those resulting in ataxia. Changes to speech lead to significant reductions in …