More than meets the eye: The role of microglia in healthy and diseased retina

E Murenu, MJ Gerhardt, M Biel… - Frontiers in …, 2022 - frontiersin.org
Microglia are the main resident immune cells of the nervous system and as such they are
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …

Adaptive optics: principles and applications in ophthalmology

E Akyol, AM Hagag, S Sivaprasad, AJ Lotery - Eye, 2021 - nature.com
This is a comprehensive review of the principles and applications of adaptive optics (AO) in
ophthalmology. It has been combined with flood illumination ophthalmoscopy, scanning …

Cone photoreceptor dysfunction in retinitis pigmentosa revealed by optoretinography

A Lassoued, F Zhang, K Kurokawa… - Proceedings of the …, 2021 - National Acad Sciences
Retinitis pigmentosa (RP) is the most common group of inherited retinal degenerative
diseases, whose most debilitating phase is cone photoreceptor death. Perimetric and …

Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo

Z Qin, S He, C Yang, JSY Yung, C Chen… - Light: Science & …, 2020 - nature.com
In vivo fundus imaging offers non-invasive access to neuron structures and biochemical
processes in the retina. However, optical aberrations of the eye degrade the imaging …

[HTML][HTML] Imaging of macrophage-like cells in living human retina using clinical OCT

MV Castanos, DB Zhou, RE Linderman… - … & visual science, 2020 - arvojournals.org
Purpose: To image retinal macrophages at the vitreoretinal interface in the living human
retina using a clinical optical coherence tomography (OCT) device. Methods: Eighteen …

Microglia phenotypes converge in aging and neurodegenerative disease

M Candlish, JK Hefendehl - Frontiers in neurology, 2021 - frontiersin.org
Microglia, the primary immune cells of the central nervous system, hold a multitude of tasks
in order to ensure brain homeostasis and are one of the best predictors of biological age on …

Imaging of vitreous cortex hyalocyte dynamics using non-confocal quadrant-detection adaptive optics scanning light ophthalmoscopy in human subjects

JV Migacz, O Otero-Marquez, R Zhou… - Biomedical Optics …, 2022 - opg.optica.org
Vitreous cortex hyalocytes are resident macrophage cells that help maintain the
transparency of the media, provide immunosurveillance, and respond to tissue injury and …

Assaying microglia functions in vitro

E Maguire, N Connor-Robson, B Shaw, R O'Donoghue… - Cells, 2022 - mdpi.com
Microglia, the main immune modulators of the central nervous system, have key roles in both
the develo** and adult brain. These functions include sha** healthy neuronal networks …

Tools and Approaches for Studying Microglia In vivo

E Eme-Scolan, SJ Dando - Frontiers in Immunology, 2020 - frontiersin.org
Microglia are specialized resident macrophages of the central nervous system (CNS) that
have important functions during neurodevelopment, homeostasis and disease. This mini …

Structural and functional distinctions of co-resident microglia and monocyte-derived macrophages after retinal degeneration

KE Ronning, SJ Karlen, ME Burns - Journal of Neuroinflammation, 2022 - Springer
Background Both resident microglia and invading peripheral immune cells can respond to
injury and degeneration in the central nervous system. However, after dead and dying …