2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force …

DK Arnett, RS Blumenthal, MA Albert… - Journal of the American …, 2019 - jacc.org
Although there has been substantial improvement in atherosclerotic cardiovascular disease
(ASCVD) outcomes in recent decades, ASCVD remains the leading cause of morbidity and …

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in …

PK Whelton, RM Carey, WS Aronow, DE Casey… - Journal of the American …, 2018 - jacc.org
As early as the 1920s, and subsequently in the 1959 Build and Blood Pressure Study (S1. 5-
1) of almost 5 million adults insured between 1934 and 1954, a strong direct relationship …

Epidemiology of cardiovascular disease in young individuals

C Andersson, RS Vasan - Nature Reviews Cardiology, 2018 - nature.com
In the past 2 decades, a high prevalence of risk factors for cardiovascular disease, such as
obesity, physical inactivity, and poor diet, has been observed among young individuals …

Cardiovascular risk factor prevalence, treatment, and control in US adults aged 20 to 44 years, 2009 to March 2020

R Aggarwal, RW Yeh, KEJ Maddox, RK Wadhera - Jama, 2023 - jamanetwork.com
Importance Declines in cardiovascular mortality have stagnated in the US over the past
decade, in part related to worsening risk factor control in older adults. Little is known about …

Trends in the prevalence, awareness, treatment, and control of hypertension among young adults in the United States, 1999 to 2014

Y Zhang, AE Moran - Hypertension, 2017 - ahajournals.org
Overall hypertension prevalence has not changed in the United States in recent decades
although awareness, treatment, and control improved. However, hypertension epidemiology …

Associations of blood pressure and cholesterol levels during young adulthood with later cardiovascular events

Y Zhang, E Vittinghoff, MJ Pletcher, NB Allen… - Journal of the American …, 2019 - jacc.org
Background: Blood pressure (BP) and cholesterol are major modifiable risk factors for
cardiovascular disease (CVD), but effects of exposures during young adulthood on later life …

Epigenetic age acceleration reflects long-term cardiovascular health

BT Joyce, T Gao, Y Zheng, J Ma, SJ Hwang… - Circulation …, 2021 - ahajournals.org
Rationale: Epigenetic aging is a novel measure of biological age, reflecting exposures and
disease risks independent of chronological age. It may serve as a useful biomarker of …

Association of genetic variants related to combined exposure to lower low-density lipoproteins and lower systolic blood pressure with lifetime risk of cardiovascular …

BA Ference, DL Bhatt, AL Catapano, CJ Packard… - Jama, 2019 - jamanetwork.com
Importance The relationship between exposure to lower low-density lipoprotein cholesterol
(LDL-C) and lower systolic blood pressure (SBP) with the risk of cardiovascular disease has …

Compounding benefits of cholesterol-lowering therapy for the reduction of major cardiovascular events: systematic review and meta-analysis

N Wang, M Woodward, MD Huffman… - … Quality and Outcomes, 2022 - ahajournals.org
Background: Mendelian randomization studies use genetic variants as natural experiments
to provide evidence about causal relations between modifiable risk factors and disease …

Trajectories of blood lipid concentrations over the adult life course and risk of cardiovascular disease and all‐cause mortality: observations from the Framingham study …

MS Duncan, RS Vasan, V Xanthakis - Journal of the American …, 2019 - ahajournals.org
Background Elevated total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C),
triglycerides, and non‐high‐density lipoprotein cholesterol (non‐HDL‐C) and low high …