Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory
L Hogarth - Neuropsychopharmacology, 2020 - nature.com
Drug addiction may be a goal-directed choice driven by excessive drug value in negative
affective states, a habit driven by strong stimulus− response associations, or a compulsion …
affective states, a habit driven by strong stimulus− response associations, or a compulsion …
Rodent models for compulsive alcohol intake
Continued seeking and drinking of alcohol despite adverse legal, health, economic, and
societal consequences is a central hallmark of human alcohol use disorders. This …
societal consequences is a central hallmark of human alcohol use disorders. This …
Habit, choice, and addiction
Addiction was suggested to emerge from the progressive dominance of habits over goal-
directed behaviors. However, it is generally assumed that habits do not persist in choice …
directed behaviors. However, it is generally assumed that habits do not persist in choice …
Memory systems and the addicted brain
The view that anatomically distinct memory systems differentially contribute to the
development of drug addiction and relapse has received extensive support. The present …
development of drug addiction and relapse has received extensive support. The present …
Bad habits–good goals? Meta-analysis and translation of the habit construct to alcoholism
Excessive alcohol consumption remains a global public health crisis, with millions suffering
from alcohol use disorder (AUD, or simply “alcoholism”), leading to significantly reduced life …
from alcohol use disorder (AUD, or simply “alcoholism”), leading to significantly reduced life …
Habitual alcohol seeking: neural bases and possible relations to alcohol use disorders
Loss of flexible control over alcohol use may contribute to the development of alcohol use
disorders. An increased contribution of response habits to alcohol‐related behaviors may …
disorders. An increased contribution of response habits to alcohol‐related behaviors may …
Defining the place of habit in substance use disorders
It has long been suggested that alcohol or substance use disorders could emerge from the
progressive development and dominance of drug habits. Like habits, drug-related behaviors …
progressive development and dominance of drug habits. Like habits, drug-related behaviors …
Intact goal‐directed control in treatment‐seeking drug users indexed by outcome‐devaluation and Pavlovian to instrumental transfer: critique of habit theory
Animal studies have demonstrated that chronic exposure to drugs of abuse impairs goal‐
directed control over action selection indexed by the outcome‐devaluation and specific …
directed control over action selection indexed by the outcome‐devaluation and specific …
Acute alcohol and cognition: Remembering what it causes us to forget
Addiction has been conceptualized as a specific form of memory that appropriates typically
adaptive neural mechanisms of learning to produce the progressive spiral of drug-seeking …
adaptive neural mechanisms of learning to produce the progressive spiral of drug-seeking …
Corticostriatal circuitry and habitual ethanol seeking
The development of alcohol-use disorders is thought to involve a transition from casual
alcohol use to uncontrolled alcohol-seeking behavior. This review will highlight evidence …
alcohol use to uncontrolled alcohol-seeking behavior. This review will highlight evidence …