Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …

Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

In this Opinion article, we summarize how changes in DNA methylation occur during aging
in mammals and discuss examples of how such events may contribute to the aging process …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

We have developed a new generation of genome-wide DNA methylation BeadChip which
allows high-throughput methylation profiling of the human genome. The new high density …

ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

DNA methylation is the most widely studied epigenetic mark and is known to be essential to
normal development and frequently disrupted in disease. The Illumina …

Tissue specific patterns of methylated cytosine residues vary with age, can be altered by
environmental factors, and are often abnormal in human disease yet the cellular …

DNA methylation in mammals is highly dynamic during germ cell and preimplantation
development but is relatively static during the development of somatic tissues. 5 …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …