Glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1)
enzymes are glutathione-S-transferases with broad significance for susceptibility or …

Statins are inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in
cholesterol biosynthesis, that are highly effective in reducing plasma low-density lipoprotein …

Introduction Racial and ethnic categories are frequently used in pharmacogenetics literature
to stratify patients; however, these categories can be inconsistent across different studies. To …

Abstract Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier
for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was …

The variation in the allelic frequencies of polymorphic pharmacogenes among different
ethnic groups may be responsible for severe adverse reactions to or altered efficacy of a …

The GSTM1 and GSTT1 genes encode homonymous enzymes, which are responsible for
the detoxification of several substances potentially harmful to the human body, such as air …

Despite all the efforts acquired in four years of the COVID-19 pandemic, the path to a full
understanding of the biological mechanisms involved in this disease remains complex. This …

Since the publication of the Human Genome Project, genetic information has been used as
an accepted, evidence‐based biomarker to optimize patient care through the delivery of …

Introduction: Research in the field of pharmacogenomics (PGx) aims to identify genetic
variants that modulate response to drugs, through alterations in their pharmacokinetics (PK) …

Purpose: This work was designed to identify the pharmacogenetic profile of Brazilian
psychiatric patients receiving psychoactive drug treatment according to ethnicity. Methods …