Cancer poses a serious health problem in society and is increasingly surpassing
cardiovascular disease as the leading cause of mortality in the United States. Current …

Biomarkers are vital in healthcare as they provide valuable insights into disease diagnosis,
prognosis, treatment response, and personalized medicine. They serve as objective …

Cancer stem cells (CSCs) have been demonstrated in a variety of tumors and are thought to
act as a clonogenic core for the genesis of new tumor growth. This small subpopulation of …

The hedgehog (SHH) signaling pathway is primarily involved in embryonic gut development,
smooth muscle differentiation, cell proliferation, adult tissue homeostasis, tissue repair …

Metastasis and resistance to therapy significantly contribute to cancer-related deaths.
Growing body of evidence suggest that altered expression of microRNAs (miRNAs) is one of …

Hyperactivated ribosome biosynthesis is attributed to a need for elevated protein synthesis
that accommodates cell growth and division, and is characterized by nucleomorphometric …

Rhabdomyosarcoma (RMS) typically arises from skeletal muscle. Currently, RMS in patients
with recurrent and metastatic disease have no successful treatment. The molecular …

GLI transcription factors have important roles in intracellular signaling cascade, acting as the
main mediators of the HH-GLI signaling pathway. This is one of the major developmental …

Background Triple-negative breast cancer (TNBC) affects young women and is the most
aggressive subtype of breast cancer (BC). TNBCs disproportionally affect women of African …

DNA damaging agents are most common in chemotherapeutic molecules that act against
cancer. However, cancer cells possess inherent biological features to overcome DNA …