Cataract, a clouding of the lens, is the most common cause of blindness in the world. It has a
marked impact on the wellbeing and productivity of individuals and has a major economic …

Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding
disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age …

The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

The lens of the eye has long been considered as a radiosensitive tissue, but recent research
has suggested that the radiosensitivity is even greater than previously thought. The 2012 …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …

The programmed removal of organelles from differentiating lens fibre cells contributes
towards lens transparency through formation of an organelle-free zone (OFZ). Disruptions in …

Recent advances have driven the development of stem cell-derived, self-organizing, three-
dimensional miniature organs, termed organoids, which mimic different eye tissues …

Maintaining protein homeostasis (proteostasis) requires precise control of protein folding
and degradation. Failure to properly respond to stresses disrupts proteostasis, which is a …

Human induced pluripotent stem cells (hiPSCs) offer unique opportunities for develo**
novel cell-based therapies and disease modeling. In this study, we developed a directed …