The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …

Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

Transepithelial/transendothelial electrical resistance (TEER) is a widely accepted
quantitative technique to measure the integrity of tight junction dynamics in cell culture …

The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …

Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-
capillary interface of the human lung. This bioinspired microdevice reproduces complex …

3D cell-culture models have recently garnered great attention because they often promote
levels of cell differentiation and tissue organization not possible in conventional 2D culture …

Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models
designed to recapitulate the important biological and physiological parameters of their in …

Tremendous progress has been achieved in the field of tissue engineering in the past
decade. Several major challenges laid down 10 years ago, have been studied, including …

Here, we present a physiologically relevant model of the human pulmonary alveoli. This
alveolar lung-on-a-chip platform is composed of a three-dimensional porous hydrogel made …