This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Abstract The flavonoids, baicalin (5, 6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-Od-β-
glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants …

Hepatic fibrosis is a scarring process that is associated with an increased and altered
deposition of extracellular matrix in liver. At the cellular and molecular level, this progressive …

The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a
characteristic response to acute or chronic liver injury. Mice were randomized to bile duct …

The cooperation between epithelial and mesenchymal cells is essential for embryonic
development and probably plays an important role in pathological phenomena such as …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths
worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments …

Fibrosis is the production of excessive amounts of connective tissue, ie, scar formation, in
the course of reactive and reparative processes. Fibrosis develops as a consequence of …

Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate
various cellular processes; however, their role in liver fibrosis is unclear. Here we investigate …

Fibrosis is a common pathological sequela of tissue injury or inflammation, and is a major
cause of organ failure. Subsets of fibroblasts contribute to tissue fibrosis in multiple ways …

Liver fibrosis is a progressive pathologic process that involves deposition of excess
extracellular matrix leading to distorted architecture and culminating in cirrhosis. The role of …