The changing metabolic landscape of bile acids–keys to metabolism and immune regulation

I Mohanty, C Allaband, H Mannochio-Russo… - Nature reviews …, 2024 - nature.com
Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …

Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy

C Campbell, MR Kandalgaonkar, RM Golonka… - Biomedicines, 2023 - mdpi.com
Gut microbes and their metabolites are actively involved in the development and regulation
of host immunity, which can influence disease susceptibility. Herein, we review the most …

Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation

M Arifuzzaman, N Collins, CJ Guo, D Artis - Immunity, 2024 - cell.com
Nutrition profoundly shapes immunity and inflammation across the lifespan of mammals,
from pre-and post-natal periods to later life. Emerging insights into diet-microbiota …

Immunomodulatory effects of inulin and its intestinal metabolites

W Sheng, G Ji, L Zhang - Frontiers in immunology, 2023 - frontiersin.org
“Dietary fiber”(DF) refers to a type of carbohydrate that cannot be digested fully. DF is not an
essential nutrient, but it plays an important part in enhancing digestive capacity and …

The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice

C Yun, S Yan, B Liao, Y Ding, X Qi, M Zhao… - Nature …, 2024 - nature.com
Polycystic ovary syndrome (PCOS), an endocrine disorder afflicting 6–20% of women of
reproductive age globally, has been linked to alterations in the gut microbiome. We …

How bile acids and the microbiota interact to shape host immunity

MH Lee, SP Nuccio, I Mohanty, LR Hagey… - Nature Reviews …, 2024 - nature.com
Bile acids are increasingly appearing in the spotlight owing to their novel impacts on various
host processes. Similarly, there is growing attention on members of the microbiota that are …

A major mechanism for immunomodulation: Dietary fibres and acid metabolites

L **e, MJ Alam, FZ Marques, CR Mackay - Seminars in immunology, 2023 - Elsevier
Diet and the gut microbiota have a profound influence on physiology and health, however,
mechanisms are still emerging. Here we outline several pathways that gut microbiota …

[HTML][HTML] Bile acids, intestinal barrier dysfunction, and related diseases

L Shi, L **, W Huang - Cells, 2023 - mdpi.com
The intestinal barrier is a precisely regulated semi-permeable physiological structure that
absorbs nutrients and protects the internal environment from infiltration of pathological …

Inulin diet uncovers complex diet-microbiota-immune cell interactions remodeling the gut epithelium

RO Corrêa, PR Castro, JL Fachi, VD Nirello… - Microbiome, 2023 - Springer
Background The continuous proliferation of intestinal stem cells followed by their tightly
regulated differentiation to epithelial cells is essential for the maintenance of the gut …

The role of diet and nutrition in allergic diseases

P Zhang - Nutrients, 2023 - mdpi.com
Allergic diseases are a set of chronic inflammatory disorders of lung, skin, and nose
epithelium characterized by aberrant IgE and Th2 cytokine-mediated immune responses to …