Featured Application The material in this article draws on, and has applications across a
range of applications in civil and structural engineering, mechanical engineering, computer …

Understanding of protein complex assembly and the effect of ligand binding on their native
topologies is integral to discerning how alterations in their architecture can affect function …

The flexibility of a solid reflects its ability to accommodate reversible changes in size or
shape. While the term is commonly used in describing physical and biological systems, a …

This book presents the singular configurations associated with a robot mechanism, together
with robust methods for their computation, interpretation, and avoidance path planning …

Modeling the instantaneous kinematics of lower pair linkages using joint screws and the
finite kinematics with Lie group concepts is well established on a solid theoretical …

Low-dimensional objects such as molecular strands, ladders, and sheets have intrinsic
features that affect their propensity to fold into 3D objects. Understanding this relationship …

Over the past two decades, we have witnessed an unprecedented explosion in available
biological data. In the age of big data, large biological datasets have created an urgent need …

Allosteric transmission refers to regulation of protein function at a distance.“Allostery”
involves regulation and/or signal transduction induced by a perturbation event. Allostery …

Since symmetry is ubiquitous in both man-made structures (eg, buildings or mechanical
linkages) and in structures found in nature (eg, proteins or crystals), it is natural to consider …

The Viral Protein 35 (VP35), a crucial protein of the Zaire Ebolavirus (EBOV), interacts with a
plethora of human proteins to cripple the human immune system. Despite its importance, the …