First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …

The complex process of apoptosis is orchestrated by caspases, a family of cysteine
proteases with unique substrate specificities. Accumulating evidence suggests that cell …

Oncosomes are tumor-derived microvesicles that transmit signaling complexes between cell
and tissue compartments. Herein, we show that amoeboid tumor cells export large (1-to 10 …

Summary Hippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis in
Drosophila. We show that the Mst1 and Mst2 protein kinases, the mammalian Hippo …

We describe a novel clinical phenotype associating T-and B-cell lymphopenia, intermittent
neutropenia, and atrial septal defects in 3 members of a consanguineous kindred. Their …

Nonalcoholic fatty liver disease (NAFLD) is a major risk factor for liver cancer; therefore, its
prevention is an important clinical goal. Ablation of phosphatase and tensin homolog …

The Hippo pathway defined originally in Drosophila melanogaster is conserved in
mammals. The fly core components Hippo, Sav, Wts, and Mats are conserved in mammals …

The “Hippo” signaling pathway has emerged as a major regulator of cell proliferation and
survival in metazoans. The pathway, as delineated by genetic and biochemical studies in …

Apoptotic cell death is a hallmark of the loss of insulin-producing beta cells in all forms of
diabetes mellitus. Current treatments fail to halt the decline in functional beta cell mass, and …

Hippo pathway downstream effectors Yap and Taz play key roles in cell proliferation and
regeneration, regulating gene expression especially via Tead transcription factors. To …