Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA
pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA …

The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to
understand the molecular processes of infection. Related flaviviruses produce noncoding …

The recent emergence of both chikungunya and Zika viruses in the Americas has
significantly expanded their distribution and has thus increased the possibility that …

Background The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously
obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health …

Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense
RNA genome that can cause serious illness in humans and animals. The 11 kb 5′ capped …

There is evidence that eukaryotic miRNAs (hereafter called host miRNAs) play a role in the
replication and propagation of viruses. Expression or targeting of host miRNAs can be …

MicroRNAs (miRNAs) are short single-stranded non-coding RNA sequences that
posttranscriptionally regulate up to 60% of protein encoding genes. Evidence is emerging …

The Flavivirus genus comprises many viruses (including dengue, Zika, West Nile and yellow
fever viruses) which constitute important public health concerns worldwide. For several of …

Vector mosquitoes are responsible for transmission of the majority of arthropod-borne (arbo-
) viruses. Virus replication in these vectors needs to be sufficiently high to permit efficient …