The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

During the last ten years, developments in cryo–electron microscopy have transformed our
understanding of eukaryotic ribosome assembly. As a result, the field has advanced from a …

Proteins and their functional interactions form the backbone of the cellular machinery. Their
connectivity network needs to be considered for the full understanding of biological …

In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal
proteins, which coassemble hierarchically during a process termed ribosome biogenesis …

Recent methodological advances allowed the identification of an increasing number of RNA-
binding proteins (RBPs) and their RNA-binding sites. Most of those methods rely, however …

During the early stages of human large ribosomal subunit (60 S) biogenesis, an ensemble of
assembly factors establishes and fine-tunes the essential RNA functional centers of pre-60 S …

The challenges posed by delayed atrophic healing and nonunion stand as formidable
obstacles in osteoporotic fracture treatment. The processes of type H angiogenesis and …

The ribonucleolytic RNA exosome interacts with RNA helicases to degrade RNA. To
understand how the 3′ to 5′ Mtr4 helicase engages RNA and the nuclear exosome, we …

The interplay between translation and mRNA decay is widespread in human cells,–. In
quality-control pathways, exonucleolytic degradation of mRNA associated with translating …