Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

Cancer is a disease of the genome caused by oncogene activation and tumor suppressor
gene inhibition. Deep sequencing studies including large consortia such as TCGA and …

B-cell chronic lymphocytic leukemia (CLL) is the most common adult leukemia. The most
common chromosomal abnormalities detectable by cytogenetics include deletion at 13q …

B-cell chronic lymphocytic leukemia (B-CLL), the most common leukemia in the Western
world, occurs in two forms, aggressive (showing for the most part high ZAP-70 expression …

Non-coding RNAs are much more common than previously thought. However, for the vast
majority of non-coding RNAs, the cellular function remains enigmatic. The two long non …

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western
countries and is characterized by the clonal expansion of mature CD5+ B cells. There have …

Purpose: To further our understanding of the biology and prognostic significance of various
chromosomal 13q14 deletions in chronic lymphocytic leukemia (CLL). Experimental Design …

Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of
chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion as the sole cytogenetic …

Historically, genes targeted by recurrent chromosomal deletions have been identified within
the smallest genomic region shared in all patients, the minimally deleted region (MDR) …