C. elegans in high-throughput drug discovery
LP O'Reilly, CJ Luke, DH Perlmutter… - Advanced drug delivery …, 2014 - Elsevier
Caenorhabditis elegans has been proven to be a useful model organism for investigating
molecular and cellular aspects of numerous human diseases. More recently, investigators …
molecular and cellular aspects of numerous human diseases. More recently, investigators …
[HTML][HTML] Advances in our understanding of nematode ion channels as potential anthelmintic targets
Ion channels are specialized multimeric proteins that underlie cell excitability. These
channels integrate with a variety of neuromuscular and biological functions. In nematodes …
channels integrate with a variety of neuromuscular and biological functions. In nematodes …
C. elegans as model for drug discovery
M Carretero, G M. Solis… - Current topics in …, 2017 - benthamdirect.com
Small molecule screens using C. elegans as a model are becoming increasingly popular as
the number of high-throughput methodologies has steadily increased over the years. Here …
the number of high-throughput methodologies has steadily increased over the years. Here …
JM McCammon, H Sive - Disease models & mechanisms, 2015 - journals.biologists.com
The treatment of psychiatric disorders presents three major challenges to the research and
clinical community: defining a genotype associated with a disorder, characterizing the …
clinical community: defining a genotype associated with a disorder, characterizing the …
Addressing the genetics of human mental health disorders in model organisms
JM McCammon, H Sive - Annual review of genomics and …, 2015 - annualreviews.org
Mental health disorders are notoriously difficult to diagnose and treat for a variety of reasons,
including genetic heterogeneity, comorbidities, and qualitative diagnostic criteria. Discovery …
including genetic heterogeneity, comorbidities, and qualitative diagnostic criteria. Discovery …
Cross Talk with the GAR-3 Receptor Contributes to Feeding Defects in Caenorhabditis elegans eat-2 Mutants
Precise signaling at the neuromuscular junction (NMJ) is essential for proper muscle
contraction. In the Caenorhabditis elegans pharynx, acetylcholine (ACh) released from the …
contraction. In the Caenorhabditis elegans pharynx, acetylcholine (ACh) released from the …
Forward Genetic Screen in Caenorhabditis elegans Suggests F57A10.2 and acp-4 As Suppressors of C9ORF72 Related Phenotypes
X Wang, L Hao, T Saur, K Joyal, Y Zhao… - Frontiers in molecular …, 2016 - frontiersin.org
An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal
mutation associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar …
mutation associated with amyotrophic lateral sclerosis (ALS)/frontotemporal lobar …
RNA polymerase II CTD S2P is dispensable for embryogenesis but mediates exit from developmental diapause in C. elegans
C Cassart, C Yague-Sanz, F Bauer, P Ponsard… - Science …, 2020 - science.org
Serine 2 phosphorylation (S2P) within the CTD of RNA polymerase II is considered a
Cdk9/Cdk12-dependent mark required for 3′-end processing. However, the relevance of …
Cdk9/Cdk12-dependent mark required for 3′-end processing. However, the relevance of …
Clozapine modulates glucosylceramide, clears aggregated proteins, and enhances ATG8/LC3 in Caenorhabditis elegans
L Hao, O Ben-David, SM Babb, AH Futerman… - …, 2017 - nature.com
Defining the mechanisms of action of the antipsychotic drug (APD), clozapine, is of great
importance, as clozapine is more effective and has therapeutic benefits in a broader range …
importance, as clozapine is more effective and has therapeutic benefits in a broader range …