Lysine degradation via formation of saccharopine is a pathway confined to the mitochondria.
The second pathway for lysine degradation, the pipecolic acid pathway, is not yet fully …

Mitochondria are best known as the sites for production of respiratory ATP and are essential
for eukaryotic life. They have their own genome but the great majority of the mitochondrial …

Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of
energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone …

Neurons require large amounts of energy, but whether they can perform glycolysis or require
glycolysis to maintain energy remains unclear. Using metabolomics, we show that human …

Meat quality has an important genetic component and can be modified by the fatty acid (FA)
composition and the amount of fat contained in adipose tissue and muscle. The present …

Thyroid disorders are clinically characterized by alterations of L-3, 5, 3', 5'-tetraiodothyronine
(T4), L-3, 5, 3'-triiodothyronine (T3), and/or thyroid-stimulating hormone (TSH) levels in the …

Histone lysine crotonylation was first identified as a new type of post-translational
modification in 2011. In recent years, prominent progress has been made in the study of …

Mitochondria-derived reactive oxygen species (mROS) are required for the survival,
proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial …

Pharmacological inhibition of mitochondrial fatty acid oxidation (FAO) has been clinically
used to alleviate certain metabolic diseases by remodeling cellular metabolism. However …

Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of liver disorders, including
the initial stage of simple fat accumulation (hepatic steatosis); followed by inflammatory …