The Drosophila larval neuromuscular system is relatively simple, containing only 32 motor
neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have …

Chemical synapses are sites of contact and information transfer between a neuron and its
partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles …

Neurotransmitters are released at presynaptic active zones (AZs). In the fly Drosophila,
monoclonal antibody (MAB) nc82 specifically labels AZs. We employ nc82 to identify …

The molecular organization of presynaptic active zones during calcium influx–triggered
neurotransmitter release is the focus of intense investigation. The Drosophila coiled-coil …

At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic
vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated …

Brain function relies on fast and precisely timed synaptic vesicle (SV) release at active zones
(AZs). Efficacy of SV release depends on distance from SV to Ca2+ channel, but molecular …

The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic
active zone (AZ) membranes has been studied in detail, and several essential components …

Synaptic vesicles fuse at active zone (AZ) membranes where Ca2+ channels are clustered
and that are typically decorated by electron-dense projections. Recently, mutants of the …

Nervous system function relies on the polarized architecture of neurons, established by
directional transport of pre-and postsynaptic cargoes. While delivery of postsynaptic …

In Drosophila, the larval neuromuscular junction is particularly tractable for studying how
synapses develop and function. In contrast to vertebrate central synapses, each presynaptic …